Dosing Regimens of Cotrimoxazole (Trimethoprim-Sulfamethoxazole) for Melioidosis
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چکیده
منابع مشابه
Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis.
Melioidosis is an infectious disease with a propensity for relapse, despite prolonged antibiotic eradication therapy for 12 to 20 weeks. A pharmacokinetic (PK) simulation study was performed to determine the optimal dosing of cotrimoxazole (trimethoprim-sulfamethoxazole [TMP-SMX]) used in current eradication regimens in Thailand and Australia. Data for bioavailability, protein binding, and coef...
متن کاملTreatment of pulmonary melioidosis with combination of trimethoprim and sulfamethoxazole.
Treatment with a combination of trimethoprim and sulfamethoxazole proved lifesaving in a patient with pulmonary melioidosis after therapeutic failure occurred with other antibiotics to which the organisms were sensitive in vitro. Antagonistic interaction of drugs occurred when the combination of trimethoprim and sulfamethoxazole was given along with other antibiotics. The combination of trimeth...
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Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a systematic review of clinical trials and observational studies that address the uti...
متن کاملOpen-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis.
Melioidosis (infection caused by Burkholderia pseudomallei) requires a prolonged course of oral antibiotics following initial intravenous therapy to reduce the risk of relapse after cessation of treatment. The current recommendation is a four-drug regimen (trimethoprim [TMP], sulfamethoxazole [SMX], doxycycline, and chloramphenicol) and a total treatment time of 12 to 20 weeks. Drug side effect...
متن کاملQuestions regarding the effectiveness of trimethoprim-sulfamethoxazole (cotrimoxazole) prophylaxis in African children.
Figure 1. Population structure of Pneumocystis carinii pneumonia (PCP) among African children as a function of cotrimoxazole prophylaxis. The total number of children is represented as A + B; the total number of children with PCP is represented as a + b. The ideal measure of risk, by cotrimoxazole use, of developing PCP is represented as (a/A)/(b/B). The actual measure of risk of developing PCP...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2009
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01301-08